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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df3302123de2a685701008f065a5caa73465cf80aed405c1885ad8c207c999f3' 
  AND token = 'JxUXZEHZ1e3N+VgQAsh/ishcDrNyjs0KpJ72SFN6HqE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}