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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '224d61e42a68bbe11a1b766916354af09ba5ad5e3dce90d261f199991490d839' 
  AND token = 'j1/xWRcI1sW6JVWF7SyiWq7iBGb+8S30S+nLqNN0Yg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}