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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a0cbfb2a0222ca3ee656ae5dca434e6352ad2a01eb7b1f0aa5f2417db48abb' 
  AND token = 'oYPdPsfAhLGC/3AnvRnDnUsYF+zVk8TRlUI3Yjol+0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}