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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '47109ea7d198ff1b65772477aa9978bfe79bfecbae971209d3e74b0e1f5a3394' 
  AND token = '2IDXM4Aq89/AD5Fi1uW2oxV4I/j4Cuc8SprPqHHyLVE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}