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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c48fcf8178def1009500375249f0674af4e9fcabe1af5e04ca9260a64ef9e21' 
  AND token = 'M+xjapTB9Br1poDaKJZ2NRaWM6DKZWxOJCQwt8ZEg5Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}