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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a399e5b3c9fae45263908ceb769c0ab95ad1263d95763673995119c85465af9' 
  AND token = 'FBbOfBfsyvBMJcv+15T8ZHarfbPL+qgHDCVMd7phAwA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}