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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43dcaa6c6cb21bc49d4d047e58014717e99b683b49f4b84c2cffbca6b2386ace' 
  AND token = 'y2ZBIOpXiQldNr4iRgswQYR05lgpu/5wXQAekYBhMdE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00078

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}