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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18b3345af52f9efc182770139fe118f33aaae9f443f9384fed64552c934d19ec' 
  AND token = 'AXZc0U2h+Erx6oMuzH/kWwoGbYrQkyF+bb3XDcdG8rc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}