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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25cfeb70ae6455ce8ab502208e11eb271c8d013a72f1c2588250b105175c643d' 
  AND token = 'EexGmuVXH/Nw8F7lMGIpAm9UfKKYWYzLbCu0at8vZ9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}