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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '185f7429d834c1b2188ffd6544d4e484edb49c3f71f143e7ecf91de9661ed546' 
  AND token = 'G+20BCWzztjt+tH6WPUNGoLTwenkjcKgXtlnpFMBrc4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}