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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd01fc9f03f4420215d09221188dc3064fccdd38de28de2e303e678e61fe2017' 
  AND token = 'wwGwio3V5gy4Iz2ub7eB+yyf198eTzBXVpeD2xkz6DA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}