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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd5cccccaea521259b951a7b4205ad97fc1dea5b5073fa76471aaa7153b06b35' 
  AND token = 'xaiy3Y/7DeoX4LEpA1bRB/7HIK0ucHxoKIEGI0vZTUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}