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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b59a3fe4dc5ca0222c077039399f1271a42a182d6b8dcea5d1e6b01570c8d80' 
  AND token = 'bbksUyesglrfJVvkJt+g8FAyFrHPYOn85LoMvv+LrM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}