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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4121219945ccac3da6c4844aa4e645aad306f21c8b17e85a746aced8e9c0584d' 
  AND token = 'u22zJpG4HwLKWeCX2NL4/2VD9hHVr3/QxzXQ5A/eAt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}