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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c12a29616a13fa0648f4b66c120b229419cf7b7ac824094ee68636f473c372d' 
  AND token = 'DJ/CRD042t9uQFkEn2Z//pvMkXyvfmA6Uq0jh0HLUsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}