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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c58466b1a29ec37382a6a7a5d3fca8e832ff0ff6fa3edc3ab1d0ecdabb117d' 
  AND token = 'yKobL+p20EyqVZyfGi69SxWl1CheoxVRMXrMb5ye6c8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}