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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3c0d339025f96deb8f3e16410a87aff215d7cc1a9c6e2d052863106234000b9' 
  AND token = 'VM1HRvi45x99S0sj7jRfxIaLoNFSMkjEEqZmanS0CjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}