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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '595e7e56b62f03c55b51dd598ac96f60561cd2ecbf29fc32cb5a58140490c46a' 
  AND token = 'Weob4qrmEB482uslT+RTFrdYhBzihq/coh0PTjfY5ng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}