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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '389a45b55440cd01a7b9853c35cb0aa53a64d94728361731a6e53fbcc44d84a5' 
  AND token = '8UplAdIOp59V5O0th+mMc4TudnSXxwCZEPZ0TSmYebw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}