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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a352f298a127bdb8f82034f49a4e88923c93b47b336833d3aa92de519b81a2' 
  AND token = 'v5P4SISgNnPORION5ei6Vlo4ZrbOFpLDocPDHovbyg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}