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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5f101664c790920fe67f9bf3b34ad4959b1cc3aa0e251a8224fce9a7278a21a' 
  AND token = 'Q+IztxEFLwARKLzO6sDUKnVrVM4vNV5IaJeh9ybNdWE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}