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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e2d4e0145738c3b52b4cbd11a5cfce0c055fe1309c7579b08596530902146a3' 
  AND token = 'aox+cFsZMtRjQWFkCp7aYoRMTa2R2NlbCaxUxCqc7mk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}