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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45d0f6c62e329dddd33ff8b9b22c9adfe48dfde642411512b61b0746166e4ba9' 
  AND token = 'DeNcoHmxFTgCnG164lzkhr8iyyvzl+hf+YL2JxxVbh8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}