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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8b549395ae024866274f1f6f4d17d2bd06db7ef8f4e046d9f1073e06255b042' 
  AND token = 'NtMJCXMeVv1Zqq3aIbhiJDjVbxtloJMtDK0zpjRbPNM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}