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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '258bd9d96787d8be37fe5dba3bd9e81c0602b6dd0a90e2889a85c2c6037af161' 
  AND token = 'p/F+Blbgh+etVYF7zxu44e4t5ntaBuz5IMIZKeBqLDc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}