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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4121dc6bd75fa25b2f04ec07374dbba576321890075502e668501ad06b81c6f6' 
  AND token = 'DP72unK3/b04mxBlImWc2R/2HzbsqEQH8e2Bg/9lqM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}