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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74e5f66c843aa117febcbe8376a0cd3c9b8c842b6638a3228bbf8d3b3ade1326' 
  AND token = 'vRXYE//bw6oM5M5PCzTz7UMbzO05SeVo2W9FAj+jIVE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}