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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b5b3df6102b60569367ba821512c66a98e217411b5971ec01ec1e9b37e4f108' 
  AND token = 'eWWlsNZSX5wHBMVmNDfPuT8v2fBXkfdFvqk8M3xHhz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}