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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e780c12a90a4554c91d15c4d40d8161900a0d9b0729072f942af429f9ee815c' 
  AND token = '1/jrCBHYwSmwCC1K0fsWlGeG+NFcSEFR7ZRWZrBMAWI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}