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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '485b7b684d6ded613c843093e752ed539bff7733a0f3b4edbce7b33f4d964b19' 
  AND token = '0R4BHl4PqXSMPoJ+N0SB991gndbj3HrAZhXOkQhzBwg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}