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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e721a1b53475aff633923c15dfba50a7aeb349f1f70d3b5794cb833d8ccbc916' 
  AND token = 'o5SoNbP2tH48umLYe734ccEtMjhprtjfKTczgL5gL9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}