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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22df38645ea22aaf3c5fcd9589ba259c5c440aeef288cb4cc5ef79af780fc643' 
  AND token = 'yxwVaBciBsw2WXYwq5I83QRT3EXynsgS+KJxywuSfN8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}