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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c22ff305b9e7c92b0b32b27e3897dc67f5d131f64244cd9548be11b8574cde3d' 
  AND token = 'gxR8JHYcgCCukR+N6kEM8U1Si9jrHkKlRXxyL+UbVMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}