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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c4f0be89c4cc5f39011379fbd7d1637c6f03dc4ac052150b509c294c5f20731' 
  AND token = 'Zzo3bINGxWb9+RSQlTbGc5xzfE0/QUTuQurzeiyzVP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}