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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e7d4ca76da40b544c6bdd95b542297387f867cbc80dd7ce0160b44392eb2b139' 
  AND token = 'JF2unTNrG2LoqxjkqCDDwS2IjMtSPmqCN9B2OPi+yxw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}