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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27e6f6cd5be34f915bfe54c9fea64a01b3a183ec4600159aa0df2729c2f24381' 
  AND token = 'tKVxg8T7Reavmy1fxhjKrMFENwXa153wB2XVQx1kMqE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}