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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7581c49e6848a34e28ab2e97c93cc289364bdd9603fb3de05a58664c69c25380' 
  AND token = 'EvCy0gd2X1Jwx1qDhUWZd4JfUMBnELcmBwazRM8MJUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}