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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53dba24c4150c9cfcae39d01747a85463439d8646999133fdf82523d3412549' 
  AND token = 'K0H0ZILA5Uc9e8glYsReFYzXGT7MMUCfTOPLzSZzAt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}