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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d591e67e663f49e33defa7d1613f807844b1bb6e473ab779217a959df873ee' 
  AND token = 'sg+2nMWG8DSY/CES0wWgAk1vpAyR5q6VNI9704vR2WM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}