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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '212649cc95c9fb42d57c9dd56c11c2b1b7311c0f11436e4d62171841b0640a0e' 
  AND token = 'y1OVkVJHSjGoUosaIrUnoVdXg1mOdWBsx8qzKSOjzag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}