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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37180ebde0648ead08fccdc1f0dffddd139df7fdc61b57cf9bc98bbee0406f49' 
  AND token = 'NBuJ4RalPeVEgaApWkYsA/7IoH+HLlw2AOW1qUnXoy8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}