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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e578735d37d3dc978c70299c9622b9edb9bbbef458137a2a29bd51648b86e7a' 
  AND token = 'majRw8DE4WEiACHgaRmeNv6hUw8ovyAlBt/yMJ9fIlY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}