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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49022cec99e2e600c12fd3abc22675eaefa2abab3278bca919129da80c3e37d3' 
  AND token = '8RbiZOD+LHVQEgJPxeWnDDMoyza0sn2j+2BaLa5H5DY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}