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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd11153f04d9197fa24918999a69dd6b68a2278b7683f21d7f27b512ac1fbf73' 
  AND token = 'SptZjVBFnr+MFOocxU8AyPvbw3DFQtI/2TbMcFS4tlY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}