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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e06e857fc598035d4d253991bc0e7859b646731b24ed43ddf6da1157eb5c3941' 
  AND token = 'N3S59Ug53Xp3BKHR8UsVDYSzF+JkRggg72/syNkztzM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}