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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '617459f8bff2ae7b2ad1b48d3ab80d31c151c84e4ffa24d75d44c81353212649' 
  AND token = 'j2AJB+pfw3JnQoPjPf+pa+gkaUJfeB/T4TQx7bsIvSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}