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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd44d0c51c6cd7c07eea47c72f8413e03d8852f5f1384f8c986ebf50925bdbb58' 
  AND token = 'cRDuFiaVkU3UfGUFPibfoKcCYUIcPaZiOt5FDWQGiOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}