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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '289e19610a07298126e63fd8713ab206f6420f946647a5cbf05eaa2cd7e4667c' 
  AND token = 'rkTrCLuyvf2bthTOrHTWwlUjFf2pYEtb9jIQ4NQVx8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}