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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66c2ded42d68b6527f2785b2de3a799dde2bcbcf563173a4123780c9d3102791' 
  AND token = 'qZ+S/gfAX8X3UZac7tW3PAR9skwQ7RFAEuZEWdbcgjc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}