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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f65c47cc22942b99fc8edd5600364a3bc88e48611fa40588cb7c12b80037229' 
  AND token = '3YiISSNhJiCPg0cWkjAPSQLDl9heQroU3XAhSWSV2hI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}